TUESDAY, OCTOBER 12, 2004 Opening Session
19:00	Greetings Blanka Rihova, Prague, Czech Republic Dinah Singer, Rockville, MD, USA Isaac P. Witz, Tel Aviv, Israel
19:45	Special Lecture R.C. Gallo, Baltimore, MD, USA THE ORIGIN OF HIV-1 ASSOCIATED KAPOSI SARCOMA: AN UPDATE Introduced by Isaac P. Witz
20:15	Get-Together Reception
WEDNESDAY, OCTOBER 13, 2004 Plenary session I - The Role of the Microenvironment in Tumor Progression Chairperson: A. Raz Session dedicated to the memory of Gabrielle Rich
08:30	Z. Werb ,San Francisco, CA, USA CELL INTERACTIONS IN THE TUMOR MICROENVIRONMENT
08:55	V. Rotter, Rehovot, Israel IDENTIFICATION OF TRANSCRIPTIONAL PROGRAMS ALONG DEFINED STAGES OF HUMAN CARCINOGENESIS
09:20	Ch. Klein, Munich, Germany FROM EPITHELIAL TRANSFORMATION TO METASTASIS: INSIGHTS FROM THE ANALYSIS OF SINGLE DISSEMINATED CANCER CELLS ISOLATED FROM MICE AND MEN
09:45	E. Tahara, Hiroshima, Japan MOLECULAR ASPECTS OF INVASION AND METASTASIS OF GASTRIC CANCER
10:10	Coffee
Plenary session IIa - Signaling & Control of Gene Expression Chairperson: E. Tahara
10:45	A. Raz, Detroit, MI, USA ENDOGENOUS GALECTIN-3 DETERMINES THE ROUTING OF FAS APOPTOTIC SIGNALING PATHWAYS
11:10	Y. Kloog, Tel Aviv, Israel GALECTIN-1(L11A) PREDICTED FROM A COMPUTED GALECTIN-1 FARNESYL BINDING POCKET IS A SELECTIVE INHIBITOR OF ACTIVE RAS-GTP
11:35	Y. Ben Neriah, Jerusalem, Israel NF-κB AT THE CROSSROAD OF INFLAMMATION AND CANCER
12:00	M. Bar-Eli, Houston, TX, USA GENE REGULATION IN MELANOMA PROGRESSION: THE ROLE OF AP-2 AND CREB
12:25	Lunch
14:00	Special Lecture I.J. Fidler, Houston, TX, USA ORGAN SPECIFIC ANTIVASCULAR THERAPY OF CANCER METASTASIS Introduced by Isaac P. Witz
Plenary session IIb - Signaling & Control of Gene Expression Chairperson: B. Sredni
14:45	F. Vidal-Vanaclocha, Leioa, Spain CONTRIBUTION OF OXIDATIVE STRESS TO MICROVASCULAR ARREST AND PROANGIOGENIC ACTIVATION OF CIRCULATING CANCER CELLS
15:10	G. Bauer, Freiburg, Germany TUMOR PROGRESSION DEPENDS ON RESISTANCE AGAINST INTERCELLULAR APOPTOSIS INDUCTION
15:35	S. Segal, Beer-Sheva, Israel INVOLVEMENT OF MHC CLASS I H-2Kb GLYCOPROTEINS IN THE REGULATION OF THE INTERFERON TYPE I SIGNAL TRANSDUCTION PATHWAY IN B16 MELANOMA CELLS
16:00	Coffee
Plenary session III - Enzymes in the Tumor Microenvironment Chairperson: S. Mohla
16:20	L.N. Matrisian, Nashville, TN, USA STROMAL MATRIX METALLOPROTEINASES IN LUNG TUMOR DEVELOPMENT
16:45	R. Fridman, Detroit, MI, USA REGULATION OF MEMBRANE TYPE-MATRIX METALLOPROTEINASES (MT-MMPS) ON THE TUMOR CELL SURFACE
17:10	R. Lupu, Evanston, IL, USA FATTY ACID SYNTHASE (FAS) A NOVEL REGULATOR OF THE ONCOGENE Her-2/neu (c-erbB-2) IN BREAST CARCINOMAS: MOLECULAR IMPLICATIONS AND TARGETED THERAPIES
17:35	G. Neufeld, Haifa, Israel THE ROLE OF LYSYL OXIDASE RELATED PROTEIN-1 (LOR-1 OR LOXL2) IN THE PROGRESSION OF BREAST CANCER
18:00	R. Bar-Shavit, Jerusalem, Israel BIOLOGY OF HUMAN PROTEASE ACTIVATED RECEPTOR-1 (HPAR1) IN MAMMARY GLAND MORPHOGENESIS, TUMOR PROGRESSION AND ANGIOGENESIS
20:00	Conference Dinner
THURSDAY, OCTOBER 14, 2004 Plenary session IV - Interactions of Cancer Cells with Stroma & ECM Chairperson: E. Yefenof Session dedicated to the memory of Diana Mary and Stanley Steyer
08:15	G.R. Cunha, San Francisco, CA, USA STROMAL CELL CONTROL OF PROSTATE CANCER PROGRESSION AND CHEMOPREVENTION
08:40	L.W.K. Chung, Atlanta, GA, USA THE BIOLOGY OF THE CROSS-TALK BETWEEN PROSTATE CANCER AND BONE AND ITS CLINICAL IMPLICATIONS
09:05	H.K. Kleinman, Bethesda, MD, USA LAMININS REGULATE ANGIOGENESIS AND TUMOR METASTASIS BY MULTIPLE ACTIVE SITES
09:30	I. Haviv, East Melbourne, VIC Australia SEGREGATING GENETIC FROM EPIGENETIC COMPONENTS OF STROMAL CONTRIBUTION TO CANCER AETIOLOGY USING MICROARRAY ANALYSIS OF INTERCELLULAR COMMUNICATIONS IN XENOGRAFT MODELS OF BREAST AND OVARIAN CANCER
09:55	W. Mikulits, Vienna, Austria EPITHELIAL PLASTICITY OF HEPATOCYTES AND LATE STAGE LIVER TUMORIGENESIS
10:20	Coffee
Plenary session V - Interactions of Cancer Cells with Growth Factors & Cytokines Chairperson: W.H. Fridman
10:45	F.R. Balkwill, London, UK CANCER AND THE CYTOKINE NETWORK
11:10	M.M. Mueller, Heidelberg, Germany GROWTH FACTORS AS PARACRINE UND AUTOCRINE MEDIATORS OF TUMOR PROGRESSION AND STROMA MODULATION
11:35	B. Sredni, Ramat-Gan, Israel AS101 {AMMONIUM TRICHLORO(DIOXOETHYLENE-O,O')TELLURATE} SENSITIZES TUMORS TO CHEMOTHERAPY BY INHIBITING TUMOR INTERLEUKIN-10 AUTOCRINE LOOP
12:00	A. Ben Baruch, Tel Aviv, Israel THE CCL5 AND CCL2 CHEMOKINES IN BREAST CANCER PROGRESSION: RECIPROCAL TUMOR-MICROENVIRONMENT INTERACTIONS
12:25	R.N. Apte, Beer-Sheba, Israel DIFFERENTIAL EFFECTS OF IL-1αAND IL-1βIN MALIGNANT PROCESSES
12:50	Lunch
14:00	Special Lecture A. Levitzki, Jerusalem, Israel INDUCING APOPTOSIS IN TUMORS: THE ROLE OF THE BY-STANDER EFFECTS Introduced by Isaac P. Witz
14:45-16:30 Symposium I - Signaling and Regulation of Gene Expression Chairperson: M. Bar-Eli
	Y. St-Pierre, Laval, QC, Canada REGULATION OF MMP GENE EXPRESSION FOLLOWING CONTACT WITH ENDOTHELIAL CELLS V. Kumar, Augusta, GA, USA INHIBITION OF HEAT SHOCK PROTEINS AFFECT NFκB FUNCTION THROUGH IKKα S. Ghosh, Basel, Switzerland THREE DIMENSIONAL SPHEROID CULTURE OF NA-8 MELANOMA CELLS INDUCES ALTERATIONS IN GENE PROFILES AS COMPARED TO MONOLAYER CULTURE: A HIGH DENSITY OLIGONUCLEOTIDE ARRAY ANALYSIS D. Radisky, Berkeley, CA, USA MMP-3-INDUCED REACTIVE OXYGEN SPECIES CAUSE GENOMIC INSTABILITY AND EPITHELIAL-MESENCHYMAL TRANSITION T. Waerner, Vienna, Austria INTERLEUKINE-LIKE EMT INDUCER (ILEI): A NEW CYTOKINE THAT INDUCES METASTATIC CAPACITY IN EPITHELIAL CELLS O. Levy-Nissenbaum, Tel Aviv, Israel THE PYST2-L PHOSPHATASE CONTROLS MICROENVIRONMENTAL SIGNALS DELIVERED THROUGH ERK AND JNK Z. Salah, Jerusalem, Israel IDENTIFICATION OF A NOVEL FUNCTIONAL ANDROGEN RESPONSE ELEMENT WITHIN HPAR1 PROMOTER: IMPLICATIONS TO PROSTATE CANCER PROGRESSION J. Zavada, Prague, Czech Republic CARBONIC ANHYDRASE IX (CA IX) MEDIATES TUMOR CELL INTERACTIONS WITH MICROENVIRONMENT
Symposium II - Interactions of Tumor Cells with Immune Components Chairperson: C. Sautès-Fridman
	D. Mezzanzanica, Milan, Italy IgCAMs IN OVARIAN CANCER PROGRESSION: CONTRIBUTE OF cDNA AND TISSUES ARRAYS IN THEIR IDENTIFICATION AND VALIDATION A. Naldini, Siena, Italy ROLE OF PROTEASE-ACTIVATED RECEPTOR-1 IN TUMOR MICROENVIRONMENT: UPREGULATION OF INTERLEUKIN IL-10 EXPRESSION G.V. Shurin, Pittsburgh, PA, USA LOSS OF NEW CHEMOKINE CXCL14 IN TUMOR TISSUE IS ASSOCIATED WITH LOW INFILTRATION BY DENDRITIC CELLS, WHILE RECOVERY OF CXCL14 EXPRESSION IN TUMORS INDUCE ANTITUMOR IMMUNITY A. Fiserova, Prague, Czech Republic THE ROLE OF CARBOHYDRATES IN NKR-P1-MEDIATED EFFECTOR-TARGET CELL INTERACTION D. Nummer, Heidelberg, Germany ADHESION-MOLECULE EXPRESSION ON T-LYMPHOCYTES AND ENDOTHELIAL CELLS: COMPARISON BETWEEN PANCREATIC CARCINOMA AND HEALTHY DONOR TISSUE R. Kok, Groningen, The Netherlands RGD-MODIFIED ANTI-CD3 ANTIBODIES REDIRECT CYTOLYTIC CAPACITY OF CYTOTOXIC T LYMPHOCYTES TOWARDS ALFA(V)BETA3-EXPRESSING ENDOTHELIAL CELLS I.E. Sotnikov, Rehovot, Israel ENZYMATICALLY QUIESCENT HEPARANASE AUGMENTS T-CELL INTERACTIONS WITH VCAM-1 AND EXTRACELLULAR MATRIX COMPONENTS UNDER VERSATILE DYNAMIC CONTEXTS
16:30	Coffee
17:00-18:45 Symposium III - Inflammation and Cancer: Interactions of Tumor Cells with Cytokines and Chemokines Chairperson: M. Pospisil
	Y. Krelin, Beer-Sheba, Israel DIFFERENTIAL INVOLVEMENT OF IL-1 ALPHA AND IL-1 BETA IN CHEMICAL CARCINOGENESIS D. Baskic, Kragujevac, Serbia, SCG SUPERNATANTS FROM PRIMARY BREAST CANCER TISSUE CULTURES INDUCES IL-18 AND NITRIC OXIDE, BUT NOT IFNγ PRODUCTION IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS IN VITRO S. Amar, Boston, MA, USA LITAF INVOLVEMENT IN P53-MODULATED APOPTOSIS L. Medina, Beer-Sheba, Israel OVER-EXPRESSION OF MATRIX METALLOPROTEINASES (MMPS)-2/9 IN OVARIAN CARCINOMA TISSUES AND CELLS; INHIBITION OF EXPRESSION BY TNF-α AND THALIDOMIDE N. Lahat, Haifa, Israel MACROPHAGE IMMOBILIZATION IN THE HYPOXIC MICROENVIRONMENT B. Azzarone, Villejuif, France A NOVEL FORM OF MEMBRANE BOUND IL-15, ANCHORED THROUGH THE IL-15RαβγCOMPLEX IS DETECTED ON HUMAN SPLEEN STROMAL CELLS: DIFFERENTIAL AND LINEAGE SPECIFIC SIGNALLING ON CIRCULATING NORMAL AND LEUKEMIC HAEMATOPOIETIC PROGENITORS EXPRESSING LOW OR HIGH AFFINITY IL-15 RECEPTORS B. Filipic, Ljubljana, Slovenia AMINO ACIDS MODULATE THE ANTIPROLIFERATIVE AND ANTIINVASIVE ACTIVITY OF HuIFN-α AGAINST CACO-2 CELLS IN VITRO H.L. Goel, Worcester, MA, USA SELECTIVE MODULATION OF TYPE 1 INSULIN-LIKE GROWTH FACTOR RECEPTOR (IGF-IR) SIGNALING AND FUNCTIONS BY β1 INTEGRINS IN CANCER CELLS
Symposium IV - Interactions of Tumor Cells with Endothelium Chairperson: M. Micksche
	E. Olaso, Leioa, Spain RESVERATROL INHIBITS THE PROANGIOGENIC RESPONSE OF HEPATIC SINUSOIDAL CELLS TO MELANOMA-DERIVED SOLUBLE FACTORS DURING LIVER METASTASIS T. Mohr, Vienna, Austria MOLECULAR PROFILING IN QUIESCENT AND VEGF-ACTIVATED HUMAN TUMOR DERIVED VASCULAR ENDOTHELIAL CELLS (HTDEC) I. Cohen, Jerusalem, Israel OVER-EXPRESSION OF HEPARANASE PROMOTES TUMOR PROGRESSION AND ANGIOGENESIS IN BREAST CANCER MODEL B. Arteta, Bizkaia, Spain PROANGIOGENIC-STIMULATING EFFECT ON STROMAL MYOFIBROBLAST ACCOUNTS FOR INCREASED LIVER METASTASIZING EFFICIENCY OF C26 COLON CARCINOMA CELLS ACTIVATED BY SOLUBLE ICAM-1 J. Brieger, Mainz, Germany VEGF-SUBTYPE SPECIFIC PROTECTION OF SCC AND HUVECs FROM RADIATION INDUCED CELL DEATH A. Zipin, Tel Aviv, Israel A POSSIBLE ROLE FOR THE FX ENZYME IN HEMATOGENOUS METASTASIS OF COLORECTAL CARCINOMA K. Jöhrer, Innsbruck, Austria THE IMPACT OF THE FAS/FASL SYSTEM ON THE TRANSENDOTHELIAL MIGRATION OF MYELOMA CELLS J.C. Rodriguez-Manzaneque, Barcelona, Spain THE CLEAVAGE OF THE TRANSMEMBRANE PROTEOGLYCAN SYNDECAN-4 BY ADAMTS1 REVEALS A NEW MECHANISM OF ACTION FOR THIS FAMILY OF PROTEASES Y. Shaked, Toronto, Ontario, Canada METRONOMIC LOW-DOSE ADMINISTRATION OF CYCLOPHOSPHAMIDE IS AN EFFECTIVE ANTIANGIOGENIC REGIMEN WITH THERAPEUTIC BENEFIT IN HEMATOLOGICAL MALIGNANCIES
FRIDAY, OCTOBER 15, 2004
8:30-10:15 Symposium V - Interactions of Tumor Cells with Extracellular Matrix Chairperson: H.K. Kleinman
	E. Corey, Seattle, WA, USA OVER-EXPRESSION OF OSTEOPROTEGERIN INHIBITS BONE LYSIS ASSOCIATED WITH PROSTATE CANCER BONE METASTASIS S.Y. Kang, Boston, MA, USA TUMOR-STROMA INTERACTION IN BREAST CANCER PROGRESSION: ROLE OF THROMBOSPONDIN-1 IN TUMOR ASSOCIATED STROMA I. Golan, Jerusalem, Israel GALECTIN 8: A NEW CD44 LIGAND AND CD44- MEDIATED APOPTOSIS INDUCER I. Shafat, Haifa, Israel SECRETION OF ACTIVE HEPARANASE FROM INTRACELLULAR POOLS IS MEDIATED BY THE PKA SIGNALING PATHWAY Y. Nadir, Haifa, Israel HEPARANASE ENHANCES TISSUE FACTOR EXPRESSION IN TUMOR CELLS K. Rmali, Cardiff, UK EXPRESSION AND PROGNOSTIC VALUE OF TUMOUR ENDOTHELIAL MARKER-8 (TEM-8) IN HUMAN COLON CANCER A. Opolski, Wroclaw, Poland THE INFLUENCE OF CALCITRIOL OR ITS ANALOG ON BETA3 INTEGRIN EXPRESSION IN A MOUSE LEWIS LUNG CARCINOMA (LLC), WEHI-3 LEUKEMIA AND B16 MELANOMA CELL LINES M. Tzukerman, Haifa, Israel A NOVEL EXPERIMENTAL PLATFORM FOR INVESTIGATING CANCER GROWTH AND ANTI-CANCER THERAPY IN A HUMAN TISSUE MICRO-ENVIRONMENT DERIVED FROM STEM CELLS
Symposium VI - Microenvironment-Based Cancer Therapy: Preclinical Studies and Clinical Trials Chairperson: A.P. Czernilofsky
	E. Voronov, Beer-Sheba, Israel THE IL-1 RECEPTOR ANTAGONIST (IL-1Ra) AS AN ANTI-TUMOR AGENT P. Vigneri, Catania, Italy BCR-ABL NUCLEAR ENTRAPMENT BY THE COMBINATION OF IMATINIB MESYLATE AND LEPTOMYCIN B KILLS CML CELLS: EX VIVO STUDY ON 35 PATIENTS M. Shehata, Vienna, Austria BONE MARROW MICROENVIRONMENT INHIBITS APOPTOSIS OF B-CLL CELLS: REGULATION BY PI3-K INHIBITORS AND SMALL INTERFERENCE RNA (SIRNA) P. Otahal, Hershey, PA, USA OVERCOMING BARRIERS TO CD8+ T CELL BASED IMMUNOTHERAPY OF PANCREATIC INSULINOMAS IN SV40 T ANTIGEN TRANSGENIC MICE D. Benayahu, Tel Aviv, Israel A NOVEL MOLECULE SEL-OB: ITS POSSIBLE ROLE IN CANCER METASTASIS B. Baguley, Auckland, New Zealand DMXAA, AN ANTICANCER AGENT WITH MULTIPLE TARGETS IN THE TUMOUR MICROENVIRONMENT M. Sirova, Prague, Czech Republic ANTI-TUMOR ACTIVITY OF HPMA-BASED DOXORUBICIN CONJUGATE CONTAINING HUMAN INTRAVENOUS IMMUNOGLOBULIN: PRECLINICAL DATA SUGGEST CYTOTOXIC EFFECT TOGETHER WITH PROTECTION OF IMMUNITY A. Reichle, Regensburg, Germany COMBINED ANTI-INFLAMMATORY AND ANGIOSTATIC TREATMENT OF HORMONE REFRACTORY PROSTATE CANCER
10:15	Coffee
Plenary session VI - Interactions of Cancer Cells with the Immunity System Chairperson: V. Schirrmacher
10:45	C. Sautès-Fridman, Paris, France EXPRESSION OF Fc GAMMA RECEPTORS BY TUMOR CELLS : AN ESCAPE TO HUMORAL IMMUNITY?
11:10	W.H. Fridman, Paris, France THE LOCAL IMMUNE REACTION AT THE EARLY STEPS OF TUMOUR SPREADING
11:35	T.L. Whiteside, Pittsburgh, PA, USA ESCAPE FOR TUMORS FROM THE HOST IMMUNE SYSTEM: MICROVESICLE-MEDIATED T-CELL APOPTOSIS
12:00	D. Zagury, Paris, France ACTIVE ANTI-VEGF AB THERAPY TO CONTROL NEOANGIOGENESIS IN MALIGNANT TUMORS
12:25	Lunch
Plenary session VIIa - Novel Therapy Modalities - From the Laboratory to the Clinic Chairperson: F. Vidal-Vanaclocha
14:00	B. Rihova, Prague, Czech Republic TUMOR-TARGETED DRUG DELIVERY BASED ON HPMA: BASIC PRINCIPLES FOR DESIGN AND TRANSFER FROM THE LABORATORY TO CLINIC
14:25	E. Keshet, Jerusalem, Israel VEGF-INDUCED NEOVASCULARIZATION: MECHANISMS AND THERAPEUTIC IMPLICATIONS
14:50	Y. Salomon, Rehovot, Israel VASCULAR-TARGETED PHOTODYNAMIC THERAPY (VTP) WITH Pd-BACTERIOPHEOPHORBIDE (TOOKAD): DEMOLITION OF A CRUCIAL NON-MALIGNANT TUMOR ELEMENT
15:15	A. Albini, Genova, Italy ANGIOPREVENTION: ANTIANGIOGENESIS IN A CHEMOPREVENTIVE SETTING
15:40	Coffee
Plenary session VIIb - Novel Therapy Modalities - From the Laboratory to the Clinic Chairperson: J. Zeromski
16:15	Y. Keisari, Tel Aviv, Israel LOW ELECTRIC FIELD CANCER TREATMENT COMBINED WITH CHEMOTHERAPY AS A TREATMENT MODALITY THAT CAN CURE MOUSE METASTATIC TUMORS
16:40	M. Pospisil, Prague, Czech Republic THE INTERACTION OF GLYCODENDRIMERS WITH TUMOR MICROENVIRONMENT
17:05	C. Lewis, Sheffield, UK USE OF MACROPHAGES TO TARGET ANTI-ANGIOGENIC THERAPY TO HYPOXIC AREAS OF SOLID TUMOURS
17:30	A. Raz, Tel Aviv, Israel ANTI-METASTATIC EFFECTS OF CYCLOOXYGENASE (COX) INHIBITORS
20:00	Farewell Evening
SATURDAY, OCTOBER 16, 2004
Plenary session VIII - The Microenvironment of Lymphatic Organs and Progression towards Metastasis Chairperson: I. Vlodavsky
08:30	M. Shurin, Pittsburgh, PA, USA REGULATION OF ANTIGEN PROCESSING AND PRESENTATION BY DENDRITIC CELLS IN THE TUMOR MICROENVIRONMENT
08:55	J. Zeromski, Poznan, Poland CAN CELL MICROENVIRONMENT OF REGIONAL LYMPH NODES IN LUNG CANCER HELP TO PREDICT THE RISK OF METASTASES?
09:20	Y. Ben-David, Toronto, Ontario, Canada THE SHAPING OF A CANCER CONDUCIVE MICROENVIRONMENT: SPLENIC STROMA OF ERYTHROLEUKEMIC MICE IS A SOURCE FOR INFLAMATION/ANGIOGENESIS MEDIATORS THAT ACCELERATE THE EXPANSION OF ERYTHROLEUKEMIA CELLS
09:45	Coffee
Plenary session IX - The Tumor Microenvironment. Clinical Trials & Applications Chairperson: R.N. Apte
10:15	V. Schirrmacher, Heidelberg, Germany CLINICAL BENEFIT OF ANTITUMOR VACCINATION OF 20 PATIENTS WITH ADVANCED HEAD AND NECK CARCINOMA AND 24 PATIENTS WITH GLIOBLASTOMA
10:40	A. Sica, Milan, Italy TUMOR ASSOCIATED MACROPHAGES AS A DISTINCT VARIANT OF M2-POLARIZED MACROPHAGES
11:05	G. Riethmueller, Munich, Germany TUMOR MICROENVIRONMENT 2004 - A SUBJECTIVE ASSESSMENT
11:30	Adjourn