Tuesday, June 25
18:00 - 20:00	Registration - Main Entrance Hall
19:30	Informal Get-Together - Terrace
Wednesday June 26
08:30	Opening and Greetings Isaac P. Witz, Tel Aviv University, Tel Aviv, Israel Peter A. Czernilofsky, Boehringer Ingelheim Austria, Vienna, Austria Norbert Kraut, Boehringer Ingelheim Austria, Vienna, Austria
Plenary Session I - Signaling and Control of Gene Expression (I)  Chairperson: P. Czernilofsky
09:00	U. Rapp, W?rzburg, Germany PROGRESSION, THERAPY AND PREVENTION OF RAF INDUCED LUNG CANCER IN MICE
09:25	Y. Ben-Neriah, Jerusalem, Israel NF-KAPPA B ACTIVATION IN CANCER: HUMAN TUMORS AND ANIMAL MODELS
09:50	A. Bardelli, Baltimore, MD, USA A PHOSPHATASE ASSOCIATED WITH METASTASIS OF COLORECTAL CANCER
10:10	S. Yaccoby, Little Rock, AR, USA TUMOR - MICROENVIRONMENT INTERACTION MODULATES GENE EXPRESSION IN MULTIPLE MYELOMA
10:30	Coffee
Special Lecture - Introduction by I. Witz
11:00	P.H. Krammer, Heidelberg, Germany IMMUNE ATTACK VS TUMOR ATTACK
Plenary Session I - Signaling and Control of Gene Expression (II)
11:40	L. Huber, Vienna, Austria EGF RECEPTOR SIGNALING REQUIRES SCAFFOLDING OF MAP KINASE ON LATE ENDOSOMES
12:05	M. Bar-Eli, Houston, TX, USA GENE REGULATION IN MELANOMA PROGRESSION: TUMOR-MICROENVIRONMENT ASSOCIATION
12:25	B. Sredni, Ramat Gan, Israel INHIBITION OF B16 MELANOMA AND GLIOMA BY AS101 VIA RAS DEPENDENT DOWNREGULATION OF IL-10
12:50	Lunch
Plenary Session II - Tumor-Endothelium Interactions (I) Chairperson: E. Yefenof
14:00	K. Alitalo, Helsinki, Finland GROWTH FACTOR REGULATION OF LYMPHANGIOGENESIS AND METASTASIS
14:25	J.A. Varner, San Diego, CA, USA REGULATION OF ANGIOGENESIS BY INTEGRIN MEDIATED SIGNAL TRANSDUCTION
14:50	E. Keshet, Jerusalem, Israel NEW INSIGHTS INTO NEOVASCULARIZATION IN THE ADULT
15:15	R. Pasqualini, Houston, TX, USA MAPPING VASCULAR DIVERSITY BY SCREENING PEPTIDE LIBRARIES
15:40	C. Kieda, Orl?ans, France ENDOTHELIAL CELLS DISTINCTIVE SIGNAL MOLECULES FOR ADHESION AND SELECTIVE TISSUE INVASION BY CIRCULATING CELLS
16:00	Coffee
Plenary Session II - Tumor-Endothelium Interactions (II) Chairperson: B. Sredni
16:30	R. Lupu, Berkeley, CA, USA INVOLVEMENT OF CYR61, AN ANGIOGENIC FACTOR, IN BREAST CANCER TUMOR PROGRESSION
16:50	G. Neufeld, Haifa, Israel THE NEUROPILINS: SPLICE VARIANT SPECIFIC VEGF CO-RECEPTORS THAT ARE DIFFERENTIALLY EXPRESSED IN ARTERIES AND VEINS
Plenary Session III - Microenvironment-Control of Cell Cycle and Apoptosis Chairperson: B. Sredni
17:10	H. Lorberboum-Galski, Jerusalem, Israel A NOVEL APPROACH OF UTILIZING APOPTOSIS FOR CANCER THERAPY
17:30	G. Bauer, Freiburg, Germany SELECTIVE APOPTOSIS INDUCTION IN TRANSFORMED CELLS THROUGH REACTIVE OXYGEN AND NITROGEN SPECIES: A POTENTIAL CONTROL STEP DURING TUMOR FORMATION
20:00	Conference Dinner Congress Casino Baden
Thursday June 27
Plenary Session IV - Adhesion and Adhesion Molecules (I) Chairperson: D. Zipori
08:45	G. Christofori, Basel, Switzerland CELL ADHESION, TUMOR INVASION, AND METASTASIS
09:10	D. Sheppard, San Francisco, CA, USA DIVERSE ROLES OF THE EPITHELIAL INTEGRIN, AVB6, IN THE DEVELOPMENT AND PROGRESSION OF EPITHELIAL TUMORS
09:35	D. Radisky, Berkeley, CA, USA MATRIX-METALLOPROTEINASE-INDUCED MALIGNANCY IN MOUSE MAMMARY EPITHELIAL CELLS
9:55	Coffee
Special Lecture - Introduction by I. Witz
10:30	R.C. Gallo, Baltimore, MD, USA The Microenvironment of Aids-associated malignancies - hiv, hhv8 and cytokines
Plenary Session IV - Adhesion and Adhesion Molecules (II) Chairperson: E. Tahara
11:10	D. Breitkreuz, Heidelberg, Germany ALTERED CELL-MATRIX INTERACTIONS OF MALIGNANT HUMAN HACAT-RAS CELLS IN NUDE MOUSE GRAFTS
11:30	H. Beug, Vienna, Austria INTEGRATION OF RECEPTOR SERINE- AND TYROSINE KINASE SIGNALS IN EPITHELIAL PLASTICITY AND METASTASIS
11:50	S. Dedhar, Vancouver, Canada INTEGRIN LINKED KINASE AND CANCER PROGRESSION
Plenary Session V - Novel Approaches for Cancer Therapy Chairperson: I. Vlodavsky
12:10	VASCULAR TARGETS FOR ANTI-CANCER THERAPY USING MONOCLONAL ANTIBODIES
12:35	Gert Riethmüller, München, Germany IMMUNOTHERAPY OF MINIMAL RESIDUAL CANCER: TRIALS AND TRIBULATIONS WITH AN ELUSIVE TARGET
13:00	Lunch
14:15 16:00	Minisymposium I - Tumor-Stroma Interactions: Adhesion and its Regulation Chairperson: E. Yefenof
	M. Willhauck, Heidelberg, Germany CONTROL OF TUMOR PHENOTYPE BY STROMAL MODULATION S. A. Leli?vre, West Lafayette, IN, USA NUMA FUNCTIONALLY LINKS CELL ADHESION AND NUCLEAR STRUCTURE TO REGULATE CELL SURVIVAL IN BREAST Z. Qin, Berlin, Germany TUMOR REJECTION BY DISTURBING TUMOR STROMA CELL INTERACTIONS J. A. Engbring, Bethesda, MD, USA A METASTASIS-PROMOTING SITE ON LAMININ-1 BINDS A HEPARAN SULFATE/CHONDROITIN SULFATE-CONTAINING PROTEOGLYCAN ON B16-F10 MELANOMA CELLS J.F. Marshall, London, UK THE C-TERMINAL 11 AMINO-ACIDS OF THE B6 INTEGRIN SUBUNIT ARE REQUIRED FOR INVASION BY SQUAMOUS CELL CARCINOMA CELLS I. Yron, Tel Aviv, Israel THE FOCAL ADHESION KINASE (P125FAK) IS CONSTITUTIVELY ACTIVE IN HUMAN MALIGNANT MELANOMA M. Parsons, Manchester, UK SITE-DIRECTED PERTURBATION OF PKC-INTEGRIN INTERACTION BLOCKS BREAST CARCINOMA CELL CHEMOTAXIS J. E. Koblinski, Bethesda, MD, USA BREAST AND PROSTATE CANCER CELL ADHESION TO OSTEONECTIN INVOLVES SYNERGY WITH FIBRONECTIN AND a5b1 INTEGRIN
14:15 16:00	Minisymposium II - Novel Approaches for Therapy Chairperson: B. Sredni
	I. Raineri, Basel, Switzerland SUPPRESSION OF AU-BINDING PROTEINS WITH SMALL INHIBITORY RNAS (SIRNAS) MODULATES EXPRESSION OF ARE CONTAINING GROWTH REGULATORS L.M. Ching, Auckland, New Zealand NFkB ACTIVATION IN TUMORS BY THE ANTI-VASCULAR AGENT DMXAA DOES NOT INDUCE RESISTANCE TO THERAPY J. M. Yingling, Indianapolis, IN, USA SMALL MOLECULE TGF-b RECEPTOR INHIBITORS ELUCIDATE A DIFFERENTIAL REQUIREMENT FOR TYPE I RECEPTOR ACTIVITY IN MEDIATING DOWNSTREAM SIGNALS D. Bisacchi, Genova, Italy NOVEL INHIBITORS OF METALLOPROTEASES AND ANGIOGENESIS, NEW USES FOR "OLD" DRUGS U. Stenram, Lund, Sweden HEAT SHOCK PROTEIN 70 (HSP70) IN INTERSTITIAL LASER THERMOTHERAPY (ILT) OF A CARCINOMA IMPLANTED INTO RAT LIVER M. Koch, Pecs, Hungary EXPRESSION STUDIES ON THE NOVEL TUMOR MARKER PIBF A. Torchinsky, Tel Aviv, Israel THE EMBRYO RESPONDING TO TERATOGENIC STRESS: A MODEL FOR DEVELOPING THERAPY SELECTIVELY TRIGGERING APOPTOSIS IN CANCER CELLS I. Golan, Jerusalem, Israel NOVEL CD44 VARIANT: POTENTIAL TARGET IN THE THERAPY OF RHEUMATOID ARTHRITIS
16:00	Coffee
16:30 18:00	Minisymposium III Tumor Invasion and Angiogenesis Chairperson: I. Vlodavsky
	L. Medina, Beer-Sheva, Israel MMP-2 AND MMP9 ARE DISTINCTLY EXPRESSED AND REGULATED IN OVARIAN CARCINOMA CELL LINE (SKOV-3) TREATED WITH THALIDOMIDE OR PRO-INFLAMMATORY CYTOKINES ANTIBODIES N. Lahat, Haifa, Israel EFFECTS OF HYPOXIA AND REOXYGENATION ON MATRIX METALLOPROTEINASE (MMP)-2 EXPRESSION IN ENDOTHELIAL CELLS Z. Salah, Jerusalem, Israel ONCOGENIC TRANSFORMATION INDUCES TUMOR ANGIOGENESIS: A ROLE FOR PAR1 ACTIVATION O. Goldshmidt, Jerusalem, Israel CELL SURFACE EXPRESSION AND SECRETION OF HEPARANASE MARKEDLY PROMOTE TUMOR ANGIOGENESIS AND METASTASIS D. Duś, Wrocław, Poland ENDOTHELIUM ORGANOSPECIFICITY EVIDENCED BY DIFFERENTIAL ADHESIVE CAPACITIES TOWARDS CANCER CELLS M.J. Grimshaw, London, UK ENDOTHELIN-2 IS A HYPOXIA-INDUCED AUTOCRINE SURVIVAL FACTOR FOR BREAST TUMOUR CELLS
16:30 18:00	Minisymposium IV - Functions of Cytokines at the Tumor Microenvironment Chairperson: R. Apte
	M.M. Müller, Heidelberg, Germany G-CSF AND GM-CSF CONTRIBUTE TO TUMOR PROGRESSION IN CLINICAL AND EXPERIMENTAL HUMAN TUMOR SYSTEMS E. Neumark, Tel-Aviv, Israel PRO-TUMORIGENIC AND ANTI-TUMORIGENIC CHEMOKINES, IL-6 AND MMPS IN MAMMARY ADENOCARCINOMA PROGRESSION: CO-REGULATION BY TNFA L. Mendoza, Leioa, Spain ENDOSTATIN INHIBITS INTERLEUKIN-18-DEPENDENT METASTASIS BY PREVENTING EFFECTS OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN TUMOR-ACTIVATED ENDOTHELIUM B. Filipič, Ljubljana, Slovenia HUMAN INTERFERON-a AFFECT THE GROWTH PROPERTIES AND MORPHOLOGY OF CELLULAR MICROTUMORS IN VITRO E. Voronov, Beer-Sheva, Israel IL-1B AS A MAJOR ACTIVATOR OF ANGIOGENESIS M.C. Dieu-Nosjean, Paris, France IL-10 INDUCES CCR6 EXPRESSION DURING LANGERHANS CELL DEVELOPMENT WHILE IL-4 AND IFN-g SUPPRESS IT
Friday June 28
08:30 10:00	Minisymposium V - The Molecular Basis of Metastasis Chairperson: D. Zipori
	C.A. Klein, München, Germany MOLECULAR-GENETIC ANALYSIS OF SINGLE DISSEMINATED TUMOR CELLS ISOLATED FROM CARCINOMA PATIENTS A. Ulmer, Tübingen, Germany QUANTITATIVE ASSESSMENT AND GENOMIC CHARACTERISATION OF OCCULT TUMOR CELLS IN PERIPHERAL BLOOD OF MELANOMA PATIENTS S. Hantisteanu, Tel Aviv, Israel THE EFFECT OF BIOLOGICAL MODIFIERS ON THE EXPRESSION LEVEL OF PYST2 mRNA IN HUMAN MYELOID LEUKEMIA CELL LINES I. Kindas-Mügge, Vienna, Austria HEAT SHOCK PROTEIN AND CANCER. OVEREXPRESSION OF THE SMALL HEAT SHOCK PROTEIN hsp27 AFFECTS THE METASTATIC PHENOTYPE OF HUMAN MELANOMA CELLS IN VITRO A.G. de Nooij-van Dalen, Amsterdam, The Netherlands MEMBERS OF THE HUMAN LY-6 ANTIGEN FAMILY AS POTENTIAL TARGETS FOR DIAGNOSIS AND THERAPY OF SQUAMOUS CELL CARCINOMA A. Eden, Cambridge, MA, USA DNA HYPOMETHYLATION CAUSES CHROMOSOMAL INSTABILITY S. Mani, Cambridge, MA, USA UNDERSTANDING HUMAN BREAST CANCER METASTASIS
08:30 10:00	Minisymposium VI - Tumor Immunity and Inflammatory Reactions Chairperson: E. Klein
	E. Klein, Stockholm, Sweden EPSTEIN BARR VIRUS (EBV) IN HODGKIN'S LYMPHOMA (HL) R. P. Ciavarra, Norfolk, VA, USA IMPACT OF THE PROSTATE TUMOR MICROENVIRONMENT ON INTRA-TUMOR DENDRITIC CELLS T. Cramer, San Diego, CA, USA HIF-1A EXPRESSION IN MYELOID CELLS IS AN ESSENTIAL REGULATOR OF INFLAMMATION N. Rosenzweig, Tel-Aviv, Israel THE POSSIBLE ROLE OF STROMAL INFLAMMATORY REAcTION IN THE PROMOTION OF PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN) IN RATS Y. Mahnke, Heidelberg, Germany A NOVEL MODEL SYSTEM FOR THE STUDY OF ANTI-TUMOUR T-CELL MEMORY T. Spies, Seattle, WA, USA MODULATION OF ANTI-TUMOR T CELL RESPONSES BY NKG2D AND ITS MIC LIGANDS
10:00	Coffee
Special Lecture - Introduction by I. Witz
10:30	I.J. Fidler, Houston, TX, USA THE ROLE OF THE ORGAN MICROENVIRONMENT IN CANCER METASTASIS
Plenary Session VI -Lytic Enzymes in the Tumor Microenvironment Chairperson: R. Apte
11:10	I. Vlodavsky, Jerusalem, Israel PROPERTIES AND FUNCTION OF HEPARANASE IN CANCER METASTASIS, ANGIOGENESIS AND NORMAL DEVELOPMENT
11:35	R. Fridman, Detroit, MI, USA REGULATION OF MEMBRANE TYPE-1 MATRIX METALLOPROTEINASES. IMPLICATION FOR PERICELLULAR PROTEOLYSIS IN TUMOR METASTASIS
12:00	R. Bar-Shavit, Jerusalem, Israel THE INVOLVEMENT OF Protease Activated Receptor1 (PAR1) IN MAMMARY GLAND MORPHOGENESIS AND TUMOR METASTASIS
12:20	Lunch
Plenary Session VII - Tumor Immunity and Immunotherapy (I) Chairperson: E. Klein
14:00	C. Sautès-Fridman, Paris, France Fc GAMMA RECEPTORS AND ST3 IN TUMOR DEVELOPMENT
14:25	M. Kirschfink, Heidelberg, Germany TUMOR CELL RESISTANCE TO COMPLEMENT-MEDIATED LYSIS: MOLECULAR MECHANISMS AND THERAPEUTIC APPROACHES
14:45	J. Zeromski, Pozna?, Poland IMMUNOBIOLOGY OF CELLS IN THE MICROENVIRONMENT OF MALIGNANT PLEURAL EFFUSIONS
15:10	M.R. Shurin, Pittsburgh, PA, USA THE DENDRITIC CELL SYSTEM UNDER TUMOR SURVEILLANCE
15:30	M. Micksche, Vienna, Austria HUMAN TUMOUR-ASSOCIATED MACROPHAGES: ROLE IN DEFENCE AGAINST CANCER CELLS
15:55	Coffee
Plenary Session VII - Tumor Immunity and Immunotherapy (II) Chairperson: I. Fidler
16:25	O. Mandelboim, Jerusalem, Israel RECEPTORS AND LIGANDS INVOLVED IN HUMAN NK CELL CYTOTOXICITY
16:45	D. Zagury, Paris, France VACCINE TO COMBAT IMMUNOSUPPRESSIVE STROMA-DERIVED FACTOR IN UTERINE CERVIX CANCER
17:05	V. Schirrmacher, Heidelberg, Germany T CELL MEMORY, ANERGY AND IMMUNOTHERAPY IN BREAST CANCER
17:30	A. Porgador, Beer Sheva, Israel MICROENVIRONMENT FOR CANCER VACCINATION: ORGAN-SPECIFIC DISTRIBUTION OF VACCINE-INDUCED CD8+ T CELLS
17:50	Y. Keisari, Tel Aviv, Israel CURE OF TUMOR BEARING MICE AND INDUCTION OF ANTITUMORAL IMMUNE RESPONSE BY A COMBINATION TREATMENT OF CHEMOTHERAPY AND INTRATUMORAL ELECTROSTIMULATION
19:30	Farewell Evening Heurigen Streiterhof, Baden
Saturday June 29
Plenary Session VIII - Cytokines in the Tumor Microenvironment Chairperson: J. Zeromski
08:30	F.R. Balkwill, London, England CYTOKINES AND CHEMOKINES IN THE TUMOR MICROENVIRONMENT
08:55	F. Vidal-Vanaclocha, Leioa, Spain CONTRIBUTION OF INTERLEUKIN-18 TO PROMETASTATIC AND PROANGIOGENIC EFFECTS OF INFLAMMATION IN THE LIVER
09:20	W.H. Fridman, Paris, France MODULATION OF ANTITUMOR IMMUNITY AND VACCINATION BY IL17 AND BACTERIAL PRODUCTS
09:45	R.N. Apte, Beer-Sheva, Israel DIFFERENTIAL EFFECTS OF IL-1α AND IL-1β IN TUMOR BIOLOGY
10:10	Coffee
Plenary Session IX - The Regulation of Tumorigenesis and Tumor Progression by Microenvironmental Factors Chairperson: I. Witz
10:30	N.E Fusenig, Heidelberg, Germany PERSISTENT STROMA ACTIVATION IS ESSENTIAL FOR TUMOR PROGRESSION AND INVASION
10:55	Y. Kloog, Tel-Aviv, Israel STRUCTURAL AND BIOCHEMICAL ANALYSIS OF RAS- GALECTIN INTERACTIONS IN CELL TRANSFORMATION
11:15	A. Raz, Detroit, MI, USA CARBOHYDRATE RECOGNITION DURING METASTASIS
11:40	B. Eliceiri, La Jolla, CA, USA Role of Integrins and Growth Factor Receptors in Angiogenesis and Tumor Formation
12:05	R.S. Johnson, La Jolla, CA, USA THE ROLE OF HYPOXIC RESPONSE IN TUMORIGENIC AND NORMAL PHYSIOLOGY
12:30	A. Haimovitz-Friedman, New York, NY, USA TPA RADIOSENSITIZES PROSTATE CANCER CELLS BY DOWN-REGULATION OF ATM
12:50	Adjourn